Anti-cancer Medicines-2

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• Topotecan is used in the treatment of ovarian cancer, small cell lung cancer, cervical cancer and cancer of colon and rectum

• Topotecan is an inhibitor of Topoisomerase, an enzyme important for replication of genetic material (DNA) in the cancer cells
• Thus it stops the growth and multiplication of cancer cells

• Fatigue, Nausea, Vomiting, Hair loss, Reduced blood platelets, Anemia, Infection, Decreased white blood cell count (neutrophils), Fever, Mucosal inflammation, Weakness, Diarrhoea, Decreased white blood cell count, Decreased appetite, Abdominal pain, Constipation

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• Pazopanib is used in the treatment of kidney cancer and soft tissue sarcoma

• In patients with cancer, a change in DNA (genetic material) triggers a signal which produces abnormal cancer cells
• Pazopanib blocks this signal, and thus stops the production of these cancer cells

• Headache, Nausea, Pain, Breathing difficulty, Vomiting, Musculoskeletal (bone, muscle or joint) pain, Fatigue, Diarrhoea, Increased blood pressure, Decreased appetite, Weight loss, Altered taste, Tumor, Abnormal skin pigmentation, Hair discolouration

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• Sorafenib is used in the treatment of liver cancer, kidney cancer, and thyroid cancer

• In patients with cancer, a change in DNA (genetic material) triggers a signal which produces abnormal cancer cells
• Sorafenib blocks this signal, and thus stops the production of these cancer cells

• Fatigue, Nausea, Loss of appetite, Diarrhoea, Abdominal pain, Hair loss, Weight loss, Rash, Hand-foot syndrome

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• Gefitinib is used in the treatment of small cell lung cancer

• In patients with cancer, a change in DNA (genetic material) triggers a signal which produces abnormal cancer cells
• Gefitinib blocks this signal, and thus stops the production of these cancer cells

• Nausea, Rash, Vomiting, Weakness, Loss of appetite, Dry skin, Diarrhoea, Stomatitis (Inflammation of the mouth)

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• Thalidomide is used in the treatment of multiple myeloma and lepra reaction

• Thalidomide modulates the activity of body''s immune system and helps indirectly attacking the cancer cells
• It also stops the growth of blood vessels in cancer

• Headache, Sleepiness, Nausea, Rash, Breathlessness, Weakness, Dizziness, Edema, Loss of appetite, Decreased white blood cell count, Decreased calcium level in blood, Weight gain, Fatigue, Muscle weakness, Fever, Anxiety, Blood clots , Dry skin, Weight loss, Confusion, Decreased white blood cell count (neutrophils), Neuropathy, Constipation, Tremor

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• Lapatinib is used in the treatment of breast cancer

• In patients with cancer, a change in DNA (genetic material) triggers a signal which produces abnormal cancer cells
• Lapatinib blocks this signal, and thus stops the production of these cancer cells

• Nausea, Headache, Back pain, Breathing difficulty, Rash, Joint pain, Pain in extremity, Insomnia (difficulty in sleeping), Vomiting, Abdominal pain, Loss of appetite, Dyspepsia, Hot flushes, Diarrhoea, Cough, Nose bleed, Constipation, Stomatitis (Inflammation of the mouth)

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• Thalidomide is used in the treatment of multiple myeloma (a type of blood cancer) and lepra reaction

• Thalidomide modulates the activity of body's immune system and helps indirectly attacking the cancer cells
• It also stops the growth of blood vessels in cancer

• Headache, Sleepiness, Nausea, Rash, Breathlessness, Weakness, Dizziness, Edema, Loss of appetite, Decreased white blood cell count, Decreased calcium level in blood, Weight gain, Fatigue, Muscle weakness, Fever, Anxiety, Blood clots , Dry skin, Weight loss, Confusion, Decreased white blood cell count (neutrophils), Neuropathy, Constipation, Tremor

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• Gemcitabine is used in the treatment of ovarian cancer, head and neck cancer, cervical cancer, testicular cancer, breast cancer, non-Hodgkin lymphoma (NHL), blood cancer, lung cancer, bone cancer and urinary bladder cancer

• Gemcitabine interferes with the growth of DNA and RNA of the cancer cells by substituting their building blocks
• It prevents the cancer cells from growing and multiplying

• Nausea, Vomiting, Loss of appetite, Hair loss, Reduced blood platelets, Allergic reaction, Breathlessness, Decreased white blood cell count, Increased liver enzymes, Anemia, Influenza like symptoms, Blood in urine, Skin rash, Protein in urine

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• Zoletrust or zoledronate is a bisphosphonate
• Zometa is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer, as well as for treating osteoporosis
• It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases
• An annual dose of Zoletrust may also prevent recurring fractures in patients with a previous hip fracture

• Diarrhea
• Abdominal pain
• Back pain
• Tooth disorder
• Indigestion